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pbuO
similar to hypoxanthine/guanine permease [protein|41DDD3AAFE89D0F52AB5ABD08CEE30A1767FFD7A|PbuG]
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.6|Nucleotide/ nucleoside transporter][category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.2|Biosynthesis/ acquisition of purine nucleotides/ based on similarity]Gene
Coordinates
3,068,908 3,070,206
The protein
Protein family
[SW|xanthine/uracil permease family] (according to UniProt)Paralogous protein(s)
[protein|41DDD3AAFE89D0F52AB5ABD08CEE30A1767FFD7A|PbuG] Expression and Regulation
Operons
genes
[gene|62AC66725C55B9E5FBBEB4EC43A88F7081B74D5C|pbuO]
description
[Pubmed|9387221]
regulatory mechanism
[protein|A8C82F5825DE0921DA6B4ACDE0CC31EC7749273C|PurR]: repression, (molecular inducer: PRPP) [Pubmed|11591660,2536750], in [regulon|A8C82F5825DE0921DA6B4ACDE0CC31EC7749273C|PurR regulon]regulation
repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|11591660,2536750]view in new tabBiological materials
Mutant
MGNA-A819 (ytiP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/819 NBRP B. subtilis, Japan]BKE29990 ([gene|62AC66725C55B9E5FBBEB4EC43A88F7081B74D5C|pbuO]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE29990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGTATCCTCCAATTACG, downstream forward: _UP4_TAAGGATAGACCAAAAAACCBKK29990 ([gene|62AC66725C55B9E5FBBEB4EC43A88F7081B74D5C|pbuO]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK29990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGTATCCTCCAATTACG, downstream forward: _UP4_TAAGGATAGACCAAAAAACCReferences
