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ykkC [Thu Dec 22 2016 10:02:19 GMT+0100 (CET)]
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ykkC [Thu Dec 22 2016 10:02:19 GMT+0100 (CET)]

putative guanidine exporter
locus
BSU13090
pI
5.00
mw
11.00 kDa
function
export/ detoxification of guanidine
product
subunit of guanidine exporter
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.11|Other exporters]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|transporters/ other], [SW|membrane proteins]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,376,517 -> 1,376,855

    The protein

    Protein family

  • paired small multidrug resistance protein family ([SW|PSMR family]) [Pubmed|17942072]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • [SW|Interactions]

  • [SW|YkkC]-[SW|YkkD] (likely) [Pubmed|17942072]

    • Expression and Regulation

    Operon

  • ''[protein|search|ykkC]-[protein|search|ykkD]'' [Pubmed|10735877]

    • Regulation

  • induced in the presence of guanidine ([SW|ykkC riboswitch]) [Pubmed|27989440]

    • Regulatory mechanism

  • [SW|ykkC riboswitch]: binding of the ligand guanidine causes transcriptional antitermination [Pubmed|27989440]
  • term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''ykkC'' [Pubmed|27120414]

    • Biological materials

    Mutant

  • MGNA-A747 (ykkC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/747 NBRP B. subtilis, Japan]

    • References

    Reviews

  • 17942072

    • Original publications

  • 15096624,10735877,21317561,27120414,27989440