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catR
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catR

[SW|MarR family|MarR/DUF24 family] transcription repressor of the [gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|AA75013C05E1A88FC51410F9F1B30EE7D15F34C2|catE] operon
locus
BSU_33680
pI
9.89
mw
26.99 kDa
protein length
108 aa Sequence Blast
gene length
327 bp Sequence Blast
function
resistance against oxidative and electrophile stress
product
[SW|MarR family|MarR/DUF24 family] transcription repressor
essential
no
synonyms
yvaP
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

    • Gene

    Coordinates
    3,457,615 3,457,941

    Phenotypes of a mutant

  • increased resistance to catechol and quinones [Pubmed|20639328]

    • The protein

    Catalyzed reaction/ biological activity

  • [SW|MarR family|MarR/DUF24 family] transcription repressor of the [gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|AA75013C05E1A88FC51410F9F1B30EE7D15F34C2|catE] operon [Pubmed|20639328]

    • Protein family

  • [SW|MarR family|MarR/DUF24 family]

    • Paralogous protein(s)

  • [protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|YodB]

    • [SW|Domains]

  • [SW|HTH hxlR-type domain] (aa 7-106) (according to UniProt)

    • Modification

  • in responsse to the presence of diamides or quinones, Cys-7 forms intermolecular disulfide bonds, this results in loss of DNA-bindig ability (induction of [gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|AA75013C05E1A88FC51410F9F1B30EE7D15F34C2|catE]) [Pubmed|20639328]

    • Structure

  • [PDB|5HS7] ([protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|YodB], 46% identity) [Pubmed|27531959]

    • Expression and Regulation

    Operons

    genes
    [gene|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-A451 (yvaP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/451 NBRP B. subtilis, Japan]
  • BKE33680 ([gene|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTTTTCACCTCGTCTG, downstream forward: _UP4_TAATTGCTAAAATGGTTCTG
  • BKK33680 ([gene|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTTTTCACCTCGTCTG, downstream forward: _UP4_TAATTGCTAAAATGGTTCTG

    • labs

  • [SW|Haike Antelmann],University of Greifswald, Germany

    • References

  • 18282125,27531959