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prfA
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prfA

peptide chain release factor 1
locus
BSU_37010
pI
4.82
mw
40.07 kDa
protein length
356 aa Sequence Blast
gene length
1071 bp Sequence Blast
function
translation
product
peptide chain release factor 1
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.11|Translation factors]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    3,797,085 3,798,155

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • binds to the ribosome through specific recognition of messenger RNA stop codons and triggers hydrolysis of the bond between the nascent polypeptide and the transfer RNA at the peptidyl-tRNA site, thereby releasing the newly synthesized protein. PrfA is highly specific for a U in the first stop-codon position and recognizes UAA and UAG

    • Protein family

  • prokaryotic/mitochondrial release factor family (with [protein|12E06FD3A36D95AE82E3C65788FA98178039592F|PrfB], according to UniProt)

    • Structure

  • [PDB|1ZBT] (from ''Streptococcus mutans'', 58% identity)

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|59E6468FD891F5271F38543515867B0B4625768D|prfA]-[gene|CF959D90A9B8F83E40E7B81CBFB00B5EC09EC0DD|prmC]-[gene|04C5876C267D77E59F57A3E7EA19C36FD35A03EF|ywkF]
    description
    [Pubmed|22383849]
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    genes
    [gene|59E6468FD891F5271F38543515867B0B4625768D|prfA]
    description
    [Pubmed|22383849]
    view in new tab

    References

  • 12237459,20512119,25217634