transcriptional regulator of transition state genes
function
regulation of gene expression during
the transition from growth to stationary phase
product
transcriptional regulator
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.6|Transition state regulators][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][SW|Categories] containing this gene/protein
[SW|transition state regulators], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)]This gene is a member of the following [SW|regulons]
[SW|SigM regulon], [SW|SigX regulon]Gene
Phenotypes of a mutant
inactivation of ''[protein|search|abh]'' results in sensitivity against beta-lactam antibiotics that can be restored by induction of ''[protein|search|slrR]'' expression or by inactivation of the genes encoding major autolysins (''[protein|search|lytC], [protein|search|lytF]'') [Pubmed|22211522]The protein
Paralogous protein(s)
[protein|search|AbrB], [SW|SpoVT] (only N-terminal domain)Structure
[PDB|2FY9] (N-terminal DNA recognition domain)[SW|Interactions]
[protein|search|Abh]-[protein|search|Abh] [Pubmed|20817675][protein|search|AbrB]-[protein|search|Abh] [Pubmed|20817675]Expression and Regulation
Operon
''[protein|search|abh]'' [Pubmed|8002614][SW|Sigma factor]
[protein|search|SigX] [Pubmed|9636707], [protein|search|SigM] [Pubmed|19465659]Regulation
expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]Labs working on this gene/protein
[SW|Mark Strauch], Baltimore, USA [http://lifesciences.umaryland.edu/Pages/faculty_profile.aspx?ID=212 homepage]References
The [SW|Abh regulon]
Other original publications
9636707,19465659,16306698,16702211,17720793,19767430,8002614,22211522,20844865,21926231 
