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sigB [2017-05-10 17:26:28]
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sigB [2017-05-10 17:26:28]

RNA polymerase sigma factor SigB
locus
BSU04730
pI
5.42
mw
29.99 kDa
protein length
264 aa Sequence Blast
gene length
792 bp Sequence Blast
function
general stress response
product
RNA polymerase sigma factor SigB
essential
no
synonyms
rpoF
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.2|Sigma factors]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.1|Sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]

    • Gene

    Coordinates
    522,862 → 523,650

    The protein

    Protein family

  • SigB subfamily (according to Swiss-Prot)

    • Structure

  • [PDB|1L0O] ([protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF]-[protein|search|SpoIIAB ]complex from Geobacillus stearothermophilus, 32% identity)

    • Expression and Regulation

    Operons

    genes
    [gene|621357D1FB6AC1B0499732EFE226F982B26CE34E|rsbR]-[gene|841CE7FCA4E84445830CA18F9856F6F30014E3BB|rsbS]-[gene|ADC52A22950736A0435AEEEC43F7407878786A81|rsbT]-[gene|0B8381D2C724DAA724E4AFC67000F12AD112D13D|rsbU]-[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]-[gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]-[gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]-[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]
    description
    [Pubmed|8002610]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8002610], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|11544224], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

    • regulatory mechanism

  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|20454630], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]

    • regulation

  • ''[protein|search|rsbV]:'' induced by stress ([protein|search|SigB]) [Pubmed|11544224]
    • view in new tab

    genes
    [gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]-[gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]-[gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]-[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]
    description
    [Pubmed|2170324]

    regulation

  • ''[protein|search|rsbV]:'' induced by stress ([protein|search|SigB]) [Pubmed|11544224]
    • view in new tab

    Biological materials

    Mutant

  • QB5344 (cat), available in the [SW|Stülke] lab
  • 1A675 ( ''sigB''::''cat''), [Pubmed|3027048], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A675&Search=1A675 BGSC]
  • 1A777 ( ''sigB''::''cat''), [Pubmed|1744042], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A777&Search=1A777 BGSC]
  • 1A780 ( ''sigB''::''spec''), [Pubmed|8253681], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A780&Search=1A780 BGSC]

    • Labs working on this gene/protein

  • [SW|Bill Haldenwang], San Antonio, USA
  • [SW|Chet Price], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]

    • References

    Reviews

  • 19575568,18035607,11407115,9767581,20658979,27518094,28271471

    • Control of SigB activity by protein-protein interactions

  • 11377871,12270815,15312768,8460143,8682769,8002610,11591687,7601843,17498739,15342582

    • Identification of the SigB regulon

  • 11544224,11532142,11717291,10482513,10220166,22174379

    • Other publications

  • 23407164,22511268,22210769,23524614,21979936,8655572,3123466,10369900,3112122,8468294,8458834,13129942,6784117,12867438,3100810,8253681,12486038,8764398,3027048,15342585,17575448,17586624,23934352,25652417,3016731,11902719,14651641,10503549,15205443,6405278,10383961,15805528,6790515,116131,39767581,19948797,22582280,24572018,24878601,27977677,28461450