aspartate-semialdehyde dehydrogenase
function
biosynthesis of threonine, lysine, dipicolic acid, peptidoglycan
product
aspartate-semialdehyde dehydrogenase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.7|Phosphorylation on a Tyr residue][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|biosynthesis/ acquisition of amino acids], [SW|Biosynthesis of cell wall components], [SW|sporulation proteins], [SW|essential genes], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|SigK regulon]Gene
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH (according to Swiss-Prot)Protein family
aspartate-semialdehyde dehydrogenase family (according to Swiss-Prot)Modification
phosphorylation on Ser-98 AND Tyr-146 [Pubmed|17218307]Structure
[PDB|2GYY] (from ''Streptococcus pneumoniae'', 52% identity, 65% similarity) [Pubmed|16895909]Expression and Regulation
Operon
''[SW|spoVFA]-[SW|spoVFB]-[protein|search|asd]-[protein|search|dapG]-[protein|search|dapA]'' [Pubmed|8098035]''[protein|search|asd]-[protein|search|dapG]-[protein|search|dapA]'' [Pubmed|8098035][SW|Sigma factor]
''[SW|spoVFA]'': [protein|search|SigK] [Pubmed|15699190,8098035]''[protein|search|asd]'': [protein|search|SigA] [Pubmed|8098035]References
8345520,15699190,8098035,17218307 
