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thrD [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]
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thrD [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

aspartokinase III
locus
BSU03790
pI
4.00
mw
49.00 kDa
function
unknown
product
aspartokinase III
essential
no
ec
2.7.2.4
synonyms
yclM
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]

    • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon], [SW|ThrR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    430,623 -> 431,987

    The protein

    Catalyzed reaction/ biological activity

  • ATP L-aspartate = ADP 4-phospho-L-aspartate (according to Swiss-Prot)

    • Protein family

  • aspartokinase family (according to Swiss-Prot)

    • Effectors of protein activity

  • inhibited by the simultaneous presence of threonine and lysine [Pubmed|11471740]

    • Expression and Regulation

    Operon

  • ''thrD'' [Pubmed|22383849]

    • Regulation

  • expressed in the presence of lysine or cysteine ([SW|ThrR]) [Pubmed|27260660]

    • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [Pubmed|23569278]
  • [protein|search|ThrR]: transcription repression [Pubmed|27260660]

    • Biological materials

    lacZ fusion

  • pBP318 (in [protein|search|pAC5]), available in [SW|Fabian Commichau]'s lab [Pubmed|27260660]

    • References

    Reviews

  • 19946135,22079167

    • Original publications

  • 11471740,23569278,2152900,2153658,22383849,27260660