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yacD
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yacD

putative peptidyl-prolyl cis-trans isomerase, similar to secretion protein [protein|6EE13E61A218A6D52BAC83A1145B0B96961CE289|PrsA]
locus
BSU_00720
pI
4.95
mw
33.94 kDa
protein length
297 aa Sequence Blast
gene length
894 bp Sequence Blast
function
unknown
product
unknown
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.6|Protein secretion/ based on similarity]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

    • Gene

    Coordinates
    80,802 81,695

    The protein

    Catalyzed reaction/ biological activity

  • [protein]-peptidylproline (ω=180) --> [protein]-peptidylproline (ω=0) (according to UniProt)
  • peptidyl-prolyl cis-trans isomerase activity (according to UniProt)

    • [SW|Domains]

  • PpiC domain (aa 154-247) (according to UniProt)

    • Structure

  • [PDB|5EZ1] (from Helicobacter pylori, 26% identity) [pubmed|26850168]

    • [SW|Localization]

  • extracellular (with signal peptide) (according to UniProt)

    • Expression and Regulation

    Operons

    genes
    [gene|9B8EAD4EDDA97526D4462F6F3205F81FECD039DE|coaX]-[gene|D579A7E4D8C3DEE4F85586C5F721CAD5FE2BCA75|yacC]-[gene|548926987569033AA0C40610B8E80FB2BB8E1E3A|yacD]-[gene|D1FC976597E5583E40A4ED7234FBCA743AB01354|cysK]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM]: sigma factor, [pubmed|18179421], in [regulon|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM regulon]

    • regulatory mechanism

  • [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]: activation, [pubmed|30480837], in [regulon|2C6386E9A63F410558D168798D077DF91590F454|Spx regulon]

    • regulation

  • induced by heat stress ([protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]) [pubmed|30480837]
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    Biological materials

    Mutant

  • MGNA-B925 (yacD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1924 NBRP B. subtilis, Japan]
  • BKE00720 ([gene|548926987569033AA0C40610B8E80FB2BB8E1E3A|yacD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE00720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAACCTGCTTTCAGCCCCT, downstream forward: _UP4_TGATTGACAAAAAATTTTGA
  • BKK00720 ([gene|548926987569033AA0C40610B8E80FB2BB8E1E3A|yacD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK00720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAACCTGCTTTCAGCCCCT, downstream forward: _UP4_TGATTGACAAAAAATTTTGA