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spoIIIAG [Mon Oct 10 2016 17:42:45 GMT+0200 (CEST)]
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spoIIIAG [Mon Oct 10 2016 17:42:45 GMT+0200 (CEST)]

component of the SpoIIIA-SpoIIQ type III secretion system residing in the forespore membrane, required for SigG activation
locus
BSU24370
pI
6.00
mw
25.00 kDa
function
activation of SigG
product
component of a type III secretion system
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|protein secretion], [SW|sporulation proteins], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|SigE regulon], [SW|SpoIIID regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,533,010 -> 2,533,699

    The protein

    [SW|Localization]

  • membrane protein [Pubmed|18485064]

    • [SW|Interactions]

  • [SW|SpoIIIAH]-[SW|SpoIIIAG] ([SW|SpoIIIAG] acts as a conduit connecting mother cell and the developing spore) [Pubmed|27681621]

    • Expression and Regulation

    Operon

  • ''[SW|spoIIIAA]-[SW|spoIIIAB]-[SW|spoIIIAC]-[SW|spoIIIAD]-[SW|spoIIIAE]-[SW|spoIIIAF]-[SW|spoIIIAG]-[SW|spoIIIAH]'' [Pubmed|18485064]
  • ''[SW|spoIIIAG]-[SW|spoIIIAH]'' [Pubmed|17693505]

    • [SW|Sigma factor]

  • [protein|search|SigE] [Pubmed|15699190]
  • both promoters: [protein|search|SigE] [Pubmed|18485064]

    • Regulation

  • both promoters: expressed during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|18485064], switched off by [SW|SpoIIID] [Pubmed|15383836]

    • Regulatory mechanism

  • [SW|SpoIIID]: transcription repression [Pubmed|15383836]

    • Additional information

  • the internal promoter is essential for sporulation, it is twice as active as the promoter in front of [protein|search|spoIIIAA], suggesting that [protein|search|SpoIIIAG] and [protein|search|SpoIIIAH] are required in larger amounts as compared to the other products of the operon [http://www.ncbi.nlm.nih.gov/sites/entrez/17693505 PubMed]

    • References

  • 1766372,18485064,17693505,19609349,27681621