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defB [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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defB [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

N-formylcysteine deformylase, required for the conversion of S-methyl-cysteine to cysteine
locus
BSU14560
pI
5.00
mw
20.00 kDa
function
utilization of S-methyl-cysteine
product
N-formylcysteine deformylase
essential
no
ec
3.5.1.88
synonyms
ykrB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.4|Sulfur metabolism] → [category|SW 2.6.4.1|Conversion of S-methyl cysteine to cysteine]

    • [SW|Categories] containing this gene/protein

  • [SW|sulfur metabolism], [SW|sporulation/ other]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,526,195 -> 1,526,749

    Phenotypes of a mutant

  • no growth with S-methyl cysteine [Pubmed|23944997]
  • inactivation of ''[SW|defB]'' reduces sporulation efficiency to 9% that of wild type cells; engulfment and fission defects, with reduced [SW|SigG] activity [Pubmed|26735940]

    • The protein

    Catalyzed reaction/ biological activity

  • N-acetylcysteine --> cysteine acetate [Pubmed|23944997]

    • Protein family

  • polypeptide deformylase family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|DefA]

    • Structure

  • [PDB|1LQY] (complex with antibiotic actinonin, Geobacillus stearothermophilus)

    • References

  • 11429456,23944997,26735940