gamma-aminobutyrate transaminase, general stress protein
function
utilization of gamma-amino butyric acid
product
gamma-aminobutyrate transaminase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.10|Utilization of gamma-amino butyric acid][SW|Categories] containing this gene/protein
[SW|utilization of amino acids]This gene is a member of the following [SW|regulons]
[SW|GabR regulon]Gene
Coordinates on the chromosome (coding sequence)
441,571 -> 442,881
Phenotypes of a mutant
growth defect in the presence of gamma-aminobutyrate [Pubmed|24127574]no growth with gamma-aminobutyrate as single carbon source [Pubmed|24529384]The protein
Catalyzed reaction/ biological activity
4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate (according to Swiss-Prot)the protein was reported to be involved in norspermidine production and biofilm disassembly [Pubmed|22541437]; however, this is not the case [Pubmed|24529384]and the original paper has been [http://www.cell.com/cell/fulltext/S0092-8674%2815%2900495-X retracted]Protein family
class-III pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|gabT]-[protein|search|gabD]'' [Pubmed|12123465][SW|Sigma factor]
[protein|search|SigA] [Pubmed|12123465]Regulation
expressed in the presence of gamma-butyric acid and pyridoxal 5'-phosphate ([protein|search|GabR]) [Pubmed|12123465]Regulatory mechanism
[protein|search|GabR]: transcription activation [Pubmed|12123465]Labs working on this gene/protein
[SW|Linc Sonenshein], Tufts University, Boston, MA, USA [http://www.tufts.edu/sackler/microbiology/faculty/sonenshein/index.html Homepage]References
15223311,12123465,22541437,24529384,4590473 
