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cca [Mon Aug 31 2015 13:55:16 GMT+0200 (CEST)]
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cca [Mon Aug 31 2015 13:55:16 GMT+0200 (CEST)]

tRNA nucleotidyltransferase, maturation of the single-copy tRNACys, which lacks an encoded CCA 3 end
locus
BSU22450
pI
8.04
mw
45.00 kDa
function
tRNA modification
product
tRNA nucleotidyltransferase
essential
yes
ec
2.7.7.25
synonyms
papS, ypjI
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
    • syns
    papS, ypjI

    [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|Spx regulon]

    • Gene

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + tRNA(n) = diphosphate + tRNA(n+1) (according to Swiss-Prot)

    • Protein family

  • the protein is similar to the ''E. coli'' poly(A) polymerase

    • Structure

  • [PDB|1MIV] (Geobacillus stearothermophilus 44% identity)

    • Expression and Regulation

    Operon

  • ''[protein|search|ypjD]-[protein|search|dapB]-[protein|search|mgsA]-[SW|bshB1]-[protein|search|bshA]-[protein|search|cca]-[protein|search|birA]'' [Pubmed|20308541]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|23894131]

    • Regulation

  • induced by diamide stess (thiol depletion) ([protein|search|Spx]) [Pubmed|23894131]

    • Regulatory mechanism

  • [protein|search|Spx]: transcription activation [Pubmed|23894131]

    • References

    Reviews

  • 19883645,16364630,20155482,18523015

    • Original publications

  • 17179213,12526808,20360175,9829937,16109934

    • Operon and expression

  • 20308541,23894131