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nadE [Mon Aug 31 2015 13:52:16 GMT+0200 (CEST)]
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nadE [Mon Aug 31 2015 13:52:16 GMT+0200 (CEST)]

NH3-dependent NAD+ synthetase
locus
BSU03130
pI
4.89
mw
30.00 kDa
function
NAD biosynthesis
product
NH3-dependent NAD+ synthetase
essential
yes
ec
6.3.1.5
synonyms
outB, tscBGH, gsp-81
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
    • syns
    outB, tscBGH, gsp-81

    [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors], [SW|general stress proteins (controlled by SigB)], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|SigB regulon]

    • Gene

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+ (according to Swiss-Prot)

    • Protein family

  • NAD synthetase family (according to Swiss-Prot)

    • Structure

  • [PDB|1KQP]

    • Expression and Regulation

    Operon

  • ''nadE'' [Pubmed|2435704]

    • [SW|Sigma factor]

  • [protein|search|SigA], [protein|search|SigB] [Pubmed|9271869,11544224]

    • Regulation

  • induced by stress ([protein|search|SigB]) [Pubmed|11544224]
  • induced by antibiotics interacting with the cytoplasmic membrane [Pubmed|22926563]

    • References

  • 9271869,8450306,19554628,11544224,22926563