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psdA [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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psdA [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

ABC transporter (ATP-binding protein) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin
locus
BSU34700
pI
6.00
mw
28.00 kDa
function
export of toxic peptides
product
ABC transporter (ATP-binding protein)
essential
no
synonyms
yvcR
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.3|Export of peptides]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|PsdR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,565,496 -> 3,566,275

    The protein

    Structure

  • [PDB|1L2T] (MJ0796 from '' Methanocaldococcus jannaschii '', 44% identity) [Pubmed|12150914]

    • [SW|Localization]

  • membrane associated (via [protein|search|PsdB]) [Pubmed|10092453]

    • [SW|Interactions]

  • [protein|search|PsdA]-[protein|search|PsdB] [Pubmed|10092453]

    • Expression and Regulation

    Operon

  • ''[protein|search|psdA]-[protein|search|psdB]'' [Pubmed|18394148]
  • ''[protein|search|psdR]-[protein|search|psdS]-[protein|search|psdA]-[protein|search|psdB]'' [Pubmed|21078927]

    • [SW|Sigma factor]

  • ''[protein|search|psdA]'': [protein|search|SigA] [Pubmed|21078927]
  • ''[protein|search|psdR]'': [protein|search|SigA] [Pubmed|21078927]

    • Regulation

  • ''[protein|search|psdA]'': induced by nisin, gallidermin ([protein|search|PsdR]) [Pubmed|21078927]
  • strongly induced in the stationary phase due to the internal production of toxic peptides ([SW|SdpC], [SW|SkfA]) ([protein|search|PsdR]) [Pubmed|26364265]
  • strong induction by [SW|SkfA], weaker induction by [SW|SdpC] [Pubmed|26364265]

    • Regulatory mechanism

  • [protein|search|PsdR]: transcription activation [Pubmed|21078927]

    • Biological materials

    Mutant

  • MGNA-B635 (yvcR::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1634 NBRP B. subtilis, Japan]

    • References

  • 18394148,10092453,21283517,26364265,12150914