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mdtP
multidrug-efflux transporter
function
multidrug resistance
product
multidrug-efflux transporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.3|Carbohydrate transporter][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
3,374,956 3,376,581
The protein
Protein family
[SW|major facilitator superfamily] (according to UniProt)[SW|EmrB family] (according to UniProt)[SW|Localization]
cell membrane (according to UniProt), membrane associated [Pubmed|18763711]Expression and Regulation
Operons
genes
[gene|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|mdtR]-[gene|45C61C1584A851676F15A2249F3F1092863C5AA5|mdtP]
description
[Pubmed|19286808]
regulatory mechanism
[protein|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|MdtR]: repression, [Pubmed|19286808], in [regulon|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|MdtR regulon]view in new tabBiological materials
Mutant
MGNA-A601 (yusP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/601 NBRP B. subtilis, Japan]BP70 (spc) available in [SW|Fabian Commichau]'s labBKE32880 ([gene|45C61C1584A851676F15A2249F3F1092863C5AA5|mdtP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE32880 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTGTTTGCCTTCTTTACTCA, downstream forward: _UP4_TAATAGAGCACCCCGCGGGTBKK32880 ([gene|45C61C1584A851676F15A2249F3F1092863C5AA5|mdtP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK32880 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTGTTTGCCTTCTTTACTCA, downstream forward: _UP4_TAATAGAGCACCCCGCGGGTReferences
