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mtnW [Mon Aug 31 2015 13:53:57 GMT+0200 (CEST)]
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mtnW [Mon Aug 31 2015 13:53:57 GMT+0200 (CEST)]

2,3-diketo-5-methylthiopentyl-1-phosphate enolase, Rubisco-like protein
locus
BSU13590
pI
5.28
mw
44.00 kDa
function
methionine salvage
product
2,3-diketo-5-methylthiopentyl-1-phosphate enolase
essential
no
synonyms
ykrW
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine]
    • syns
    ykrW

    [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]

    • This gene is a member of the following [SW|regulons]

  • [SW|S-box]

    • The protein

    Catalyzed reaction/ biological activity

  • 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (according to Swiss-Prot)

    • Protein family

  • Type IV subfamily (according to Swiss-Prot)

    • Structure

  • [PDB|2ZVI] [Pubmed|19690372]

    • Expression and Regulation

    Operon

  • ''[protein|search|mtnW]-[protein|search|mtnX]-[protein|search|mtnB]-[protein|search|mtnD]'' [Pubmed|12022921]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|12022921]

    • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]

    • Regulatory mechanism

  • [protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]

    • References

  • 10094622,19279009,12022921,14551435,11914366,12107147,19194007,15102328,19690372,12787499,18039762