product
valyl-tRNA synthetase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.11|Efp-dependent proteins][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|T-box], [SW|Efp-dependent proteins]Gene
Coordinates on the chromosome (coding sequence)
2,866,664 -> 2,869,306
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP L-valine tRNA(Val) = AMP diphosphate L-valyl-tRNA(Val) (according to Swiss-Prot) Protein family
ValS type 1 subfamily (according to Swiss-Prot)Structure
[PDB|1IYW] (from ''Thermus thermophilus'', 41% identity, 60% similarity) [Pubmed|12554880]Expression and Regulation
Operon
''[protein|search|valS]-[protein|search|folC]'' [Pubmed|9098041][SW|Sigma factor]
[protein|search|SigA] [Pubmed|9098041]Regulation
induced by valine limitation ([protein|search|T-box]) [Pubmed|9098041,19258532]Regulatory mechanism
[protein|search|T-box]: [SW|riboswitch], transcription termination/antitermination [Pubmed|9098041,19258532]Additional information
[protein|search|translation] is likely to require [protein|search|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
Reviews
Original Publications
9098041,15378759,25310979 
