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murC
UDP-N-acetylmuramoyl-L-alanine synthetase
function
peptidoglycan precursor biosynthesis
product
UDP-N-acetylmuramoyl-L-alanine synthetase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]Gene
Coordinates
3,048,177 3,049,475
Phenotypes of a mutant
essential [Pubmed|12682299]murC is dispensable in wall-less L-forms [Pubmed|24704074]The protein
Catalyzed reaction/ biological activity
ATP + L-alanine + UDP-N-acetyl-α-D-muramate --> ADP + H+ + phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanine (according to UniProt)Protein family
[SW|MurCDEF family] (according to UniProt)Structure
[PDB|1GQQ] (from Haemophilus influenzae, 31% identity)[SW|Localization]
cytoplasm (Homogeneous) [Pubmed|16479537]forms banded patterns along the length of the cell, this pattern formation depends on [protein|A4C8719E06F774A6EB4D79757CC79CF89E453A54|MreB] [Pubmed|20233306]Expression and Regulation
Operons
genes
[gene|3BF530AB1B6A3DB3671FC046E2B38CA1936E6F78|murC]
description
[Pubmed|8733232]
genes
[gene|DF77B46666595E86081C5345C91E08F86DF9FAEE|sftA]-[gene|3BF530AB1B6A3DB3671FC046E2B38CA1936E6F78|murC]
description
[Pubmed|22383849]
References
18063720,8733232,24704074,16479537,20233306 
