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phoB [Mon May 30 2016 18:26:11 GMT+0200 (CEST)]
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phoB [Mon May 30 2016 18:26:11 GMT+0200 (CEST)]

alkaline phosphatase III, heptaprenylglyceryl phosphate processing phosphatase
locus
BSU05740
pI
5.00
mw
50.00 kDa
function
aquisition of phosphate upon phosphate starvation, ether lipid synthesis
product
alkaline phosphatase III, heptaprenylglyceryl phosphate processing phosphatase
essential
no
ec
3.1.3.1
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.3|Phosphate metabolism]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|phosphate metabolism], [SW|sporulation proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|PhoP regulon], [SW|SigE regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    620,097 -> 621,485

    The protein

    Catalyzed reaction/ biological activity

  • A phosphate monoester H2O = an alcohol phosphate (according to Swiss-Prot)
  • Protein family

  • alkaline phosphatase family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|PhoA]
  • Modification

  • phosphorylated on ser/ thr/ tyr [Pubmed|16493705]
  • Structure

  • [PDB|3A52] (from ''Shewanella sp.'', 41% identity) [Pubmed|20057143]
  • [SW|Localization]

  • extracellular (signal peptide) [Pubmed|18957862]
  • Expression and Regulation

    Operon

  • ''[protein|search|phoB]-[protein|search|ydhF]'' [Pubmed|10913081]
  • [SW|Sigma factor]

  • [protein|search|SigA], [protein|search|SigE] [Pubmed|15699190,16030210]
  • Regulation

  • expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|9335276,10913081,16030210]
  • Regulatory mechanism

  • [protein|search|PhoP]: transcription activation [Pubmed|9335276,10913081,16030210]
  • Biological materials

    Mutant

  • 1A767 ( ''phoB''::''cat''), [Pubmed|9426145], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A767&Search=1A767 BGSC]
  • References

  • 16030210,9335276,8088554,10913081,16491025,8113174,9335276,18957862,16493705,25666134,20057143,27118079,27226549