You are currently viewing an outdated version of
SubtiWiki.
Please use
the newest version!
yoaD [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]
similar to phosphoglycerate dehydrogenase
function
methionine biosynthesis
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.11|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine/ based on similarity][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]This gene is a member of the following [SW|regulons]
[SW|S-box]Gene
Coordinates on the chromosome (coding sequence)
2,024,042 -> 2,025,076
The protein
Catalyzed reaction/ biological activity
YoaD is likely to convert 3-phosphoglycerate to serine for use in methionine biosynthesis (based on [protein|search|S-box] regulation)Additional information
The gene is annotated in KEGG as an ortholog of D-3-phosphoglycerate dehydrogenase EC 1.1.1.95. No EC annotation is available in Swiss-Prot. In MetaCyc the protein is marked as “similar to phosphorglycerate dehydrogenase”. No literature/experimental evidence supporting the annotation is available. [Pubmed|19935659]Expression and Regulation
Operon
''[protein|search|yoaD]-[protein|search|yoaC]-[protein|search|yoaB]'' [Pubmed|10094622]Regulation
repressed by casamino acids [Pubmed|12107147]induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]Regulatory mechanism
[protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]References
19258532,10094622,12107147,18039762 
