function
purine salvage and interconversion
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.3|Purine salvage and interconversion][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|PurR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,303,042 -> 3,304,022
The protein
Catalyzed reaction/ biological activity
Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH (according to Swiss-Prot)Protein family
GuaC type 2 subfamily (according to Swiss-Prot)Structure
[PDB|1YPF] (from ''Bacillus anthracis'', 84% identity, 91% similarity)Expression and Regulation
Operon
''guaC'' [Pubmed|21815947]Regulation
repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|11591660]activated during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]expression activated by glucose (3.3 fold) [Pubmed|12850135]Regulatory mechanism
[protein|search|CodY]: transcription activation [Pubmed|12618455][protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750]Additional information
the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] (the half-life of the mRNA increases from 3 to 20 min) [PubMed|21815947]References
11591660,2536750,12618455,12850135,21815947 
