SubtiBank SubtiBank
ycbJ [2019-06-18 09:38:36]
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ycbJ [2019-06-18 09:38:36]

similar to macrolide 2-phosphotransferase
locus
BSU02520
pI
4.57
mw
34.33 kDa
protein length
306 aa Sequence Blast
gene length
921 bp Sequence Blast
function
unknown
product
unknown
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.14|Resistance against toxins/ antibiotics/ based on similarity]

    • Gene

    Coordinates
    275,838 276,758

    The protein

    Protein family

  • aminoglycoside phosphotransferase family (according to Swiss-Prot)

    • Structure

  • [PDB|5IGV] (from E. coli, 43% identity) [pubmed|28416110]

    • Expression and Regulation

    Operons

    genes
    [gene|3542BC20C11985B3CFAA4F930E8D794700ADFD2E|ycbC]-[gene|5B66ADB81AB141982F187B1C5E3A9346AA064DE2|ycbD]-[gene|9C4932DA4DEF99263E57871A99684E3DAD93E1EC|ycbE]-[gene|372F2A420309DB0193AEF36A740EBA26410F97F2|ycbF]-[gene|1A65880F68898002EE8774F34EDC47F0243B7273|ycbG]-[gene|BA556E144975921DFDD598B0A7480C65176F0F14|ycbH]-[gene|349C99C258331962455100E2662DA2272E946C8A|ycbJ]
    description
    [Pubmed|12044674]

    regulatory mechanism

  • [protein|1A65880F68898002EE8774F34EDC47F0243B7273|YcbG]: repression, [Pubmed|12044674], in [regulon|1A65880F68898002EE8774F34EDC47F0243B7273|YcbG regulon]
  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|18840696], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]

    • regulation

  • induced by D-glucarate/galactarate ([protein|search|YcbG]) [Pubmed|12044674]
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    Biological materials

    Mutant

  • MGNA-C032 (ycbJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2030 NBRP B. subtilis, Japan]
  • BKE02520 ([gene|349C99C258331962455100E2662DA2272E946C8A|ycbJ]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE02520 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCCATTTCCCCTTTCTC, downstream forward: _UP4_TAAGAATTGACTTCGTTTCA
  • BKK02520 ([gene|349C99C258331962455100E2662DA2272E946C8A|ycbJ]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK02520 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCCATTTCCCCTTTCTC, downstream forward: _UP4_TAAGAATTGACTTCGTTTCA

    • References

  • 12044674,18840696,28416110