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papA [2017-8-11 16:0:3]

Xaa-Pro amino-peptidase

locus

BSU24460

4.83

37.96 kDa

protein length

353 aa Sequence Blast

gene length

1059 bp Sequence Blast

function

degradation of proline-containing peptides

product

Xaa-Pro amino-peptidase

essential

3.4.11.9

synonyms

yqhT

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.4|Utilization of peptides]

[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]

Gene

Coordinates

2,538,697 → 2,539,758

Phenotypes of a mutant

inactivation of ''[gene|33886A1EAC13B684E92BF94201C46617AD2844B3|papA]'' reduces sporulation efficiency to 1.2% that of wild type cells; delayed entry into sporulation [Pubmed|26735940]

The protein

Protein family

peptidase M24B family (according to Swiss-Prot)

Paralogous protein(s)

[protein|C95EEAC79B9E823BBBCF6B1960DABCCBB2AC03A4|PapB]

Structure

[PDB|3Q6D] (the ''B. anthracis'' enzyme, 65% identity, 82% similarity)

[SW|Localization]

cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

genes

description

[pubmed|22383849]

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genes

description

[pubmed|22383849]

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Biological materials

Mutant

MGNA-C447 (yqhT::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2445 NBRP B. subtilis, Japan]

available in the [SW|Erhard Bremer] lab

Labs working on this gene/protein

[SW|Erhard Bremer], Marburg University, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi Homepage]

References

23144141,26735940