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hemD [Mon Aug 31 2015 13:56:04 GMT+0200 (CEST)]
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hemD [Mon Aug 31 2015 13:56:04 GMT+0200 (CEST)]

uroporphyrinogen-III synthase
locus
BSU28140
pI
5.09
mw
28.00 kDa
function
heme biosynthesis
product
uroporphyrinogen-III synthase
essential
no
ec
4.2.1.75
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • This gene is a member of the following [SW|regulons]

  • [SW|PerR regulon]

    • The protein

    Catalyzed reaction/ biological activity

  • Hydroxymethylbilane = uroporphyrinogen III + H2O (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|hemA]-[protein|search|hemX]-[protein|search|hemC]-[protein|search|hemD]-[protein|search|hemB]-[protein|search|hemL]'' [Pubmed|1672867]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1672867]

    • Regulation

  • induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]

    • Regulatory mechanism

  • [protein|search|PerR]: transcription repression [Pubmed|11532148]

    • References

  • 10217486,1672867,7628476,11532148,22960854