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deoD

purine nucleoside phosphorylase

locus

BSU_19630

4.98

25.23 kDa

protein length

233 aa Sequence Blast

gene length

702 bp Sequence Blast

function

purine salvage and interconversion

product

purine nucleoside phosphorylase

essential

2.4.2.1

synonyms

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.3|Purine salvage and interconversion]

Gene

Coordinates

2,135,470 2,136,171

The protein

Catalyzed reaction/ biological activity

purine D-ribonucleoside + phosphate --> purine nucleobase + α-D-ribose 1-phosphate (according to UniProt)

purine 2'-deoxy-D-ribonucleoside + phosphate --> 2-deoxy-α-D-ribose 1-phosphate + purine nucleobase (according to UniProt)

Protein family

PNP/UDP phosphorylase family (with [protein|5B21D1E73A65B13CE4DDA32ABC71EFA54E8D1D8F|MtnN], according to UniProt)

Structure

[PDB|4D8V] [Pubmed|22957058]

Expression and Regulation

Operons

genes

[gene|3075327DBE55C4F628171AEE248CAED5870693FA|deoD]-[gene|9A22825FD67B6A205807433D0B4908F86E5AB343|ldcB]

description

[Pubmed|22383849]

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Biological materials

Mutant

BKE19630 ([gene|3075327DBE55C4F628171AEE248CAED5870693FA|deoD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE19630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTCATATCCTCCTGTAA, downstream forward: _UP4_TAAAATATATCAAGAGGCGT

BKK19630 ([gene|3075327DBE55C4F628171AEE248CAED5870693FA|deoD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK19630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTCATATCCTCCTGTAA, downstream forward: _UP4_TAAAATATATCAAGAGGCGT

References

21424839,16511068,22957058,22383849