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tsaD [Mon Jan 18 2016 18:18:50 GMT+0100 (CET)]
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tsaD [Mon Jan 18 2016 18:18:50 GMT+0100 (CET)]

required for threonyl carbamoyl adenosine (t6A) modification of tRNAs that pair with ANN codons in mRNA (together with TsaC), universally conserved protein
locus
BSU05940
pI
5.00
mw
36.00 kDa
function
tRNA modification
product
tRNA modification enzyme
essential
yes
ec
2.3.1.234
synonyms
ydiE, gcp
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes], [SW|universally conserved proteins]

    • Gene

    Coordinates on the chromosome (coding sequence)
    643,258 -> 644,298

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • biosynthesis of the threonylcarbamoyladenosine (t6A) residue at position 37 of ANN-decoding tRNAs using L-threonylcarbamoyl-AMP ([protein|search|TsaB]-[protein|search|TsaD]-[protein|search|TsaE]) [Pubmed|23072323,21183954]

    • Structure

  • [PDB|3ZET] (from ''Salmonella typhimurium'', 46% identity)

    • [SW|Interactions]

  • [protein|search|TsaB]-[protein|search|TsaD] [Pubmed|23072323,21285948]
  • [protein|search|TsaD]-[protein|search|TsaE] [Pubmed|23072323]

    • Additional information

  • [SW|universally conserved protein]

    • Expression and Regulation

    Operon

  • ''[protein|search|thiL]-[protein|search|tsaE]-[protein|search|tsaB]-[protein|search|ydiD]-[protein|search|tsaD]'' [Pubmed|22383849]

    • References

    Publications on the corresponding protein from other species

  • 21183954,19376873,20824107,21619589,21285948,21625506,23056478