phospho-alpha-glucosidase
function
trehalose utilization
product
phospho-alpha-glucosidase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.20|Utilization of trehalose][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|PhoP regulon], [SW|TreR regulon]Gene
Coordinates on the chromosome (coding sequence)
851,850 -> 853,535
The protein
Catalyzed reaction/ biological activity
Alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate (according to Swiss-Prot)Protein family
glycosyl hydrolase 13 family (according to Swiss-Prot)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|treP]-[protein|search|treA]-[protein|search|treR]'' [Pubmed|8755887][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8755887]Regulation
induced by trehalose ([protein|search|TreR]) [Pubmed|8755887]repressed by glucose ([protein|search|CcpA]) [Pubmed|18977770]expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|21636651]Regulatory mechanism
[protein|search|TreR]: transcription repression [Pubmed|8755887][protein|search|CcpA]: transcription repression [Pubmed|18977770][protein|search|PhoP]: transcription activation [Pubmed|21636651]Biological materials
Mutant
GP1118 (spc), available in the [SW|Stülke] labReferences
8755887,7651129,7751281,8917076,18977770 
