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pgsA [Tue Nov 08 2016 10:32:18 GMT+0100 (CET)]
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pgsA [Tue Nov 08 2016 10:32:18 GMT+0100 (CET)]

phosphatidylglycerophosphate synthase
locus
BSU16920
pI
5.00
mw
21.00 kDa
function
biosynthesis of phospholipids
product
phosphatidylglycerophosphate synthase
essential
yes
ec
2.7.8.5
synonyms
ymfN
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of lipids], [SW|essential genes], [SW|membrane proteins]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,762,623 -> 1,763,204

    Phenotypes of a mutant

  • some point mutations resulting in reduced PgsA activity lead to daptomycin resistance [Pubmed|21709092]essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • CDP-diacylglycerol sn-glycerol 3-phosphate = CMP 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (according to Swiss-Prot)

    • Protein family

  • CDP-alcohol phosphatidyltransferase class-I family (according to Swiss-Prot)

    • [SW|Localization]

  • cell membrane at the septum [Pubmed|19820159,15743965]

    • Biological materials

    Mutant

  • 1A815 ( ''pgsA''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A815&Search=1A815 BGSC]

    • References

  • 19745567,16514141,19820159,15743965,21709092