riboflavin synthase (beta subunit)
function
riboflavin biosynthesis
product
riboflavin synthase (beta subunit)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.2|Biosynthesis/ acquisition of riboflavin/ FAD][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors]This gene is a member of the following [SW|regulons]
[SW|FMN-box]Gene
Coordinates on the chromosome (coding sequence)
2,427,892 -> 2,428,356
The protein
Catalyzed reaction/ biological activity
2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine (according to Swiss-Prot)Protein family
DMRL synthase family (according to Swiss-Prot)Structure
[PDB|1ZIS], [PDB|1RVV] (the [protein|search|RibE])3-([protein|search|RibH])60 lumazine synthase/riboflavin synthase complex) [Pubmed|7473709][SW|Interactions]
([protein|search|RibE])3-([protein|search|RibH])60, the lumazine synthase/riboflavin synthase complex [Pubmed|7473709]Expression and Regulation
Operon
''[protein|search|ribD]-[protein|search|ribE]-[protein|search|ribA]-[protein|search|ribH]-[protein|search|ribT]'' [Pubmed|8159171][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8159171]Regulation
expressed in the absence of FMN ([protein|search|FMN-box]) [Pubmed|15808508]Regulatory mechanism
[protein|search|FMN-box]: [SW|riboswitch], mediates termination of transcription in the presence of FMN or FMNH2, this is counter-acted upon binding of [SW|RibR] [Pubmed|26494285], [Pubmed|15808508]References
12456892,15808508,7473709,8159171,7934830,3100522,23270261,24442413,26494285 
