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nadF [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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nadF [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

NAD kinase
locus
BSU11610
pI
5.00
mw
29.00 kDa
function
generation of NADP from NAD
product
inorganic polyphosphate/ATP-NAD kinase
essential
yes
ec
2.7.1.23
synonyms
yjbN, ppnK
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors], [SW|essential genes]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,237,660 -> 1,238,460

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP NAD = ADP NADP (according to Swiss-Prot)

    • Protein family

  • NAD kinase family (according to Swiss-Prot)

    • Effectors of protein activity

  • allosterically activated by quinolinic acid

    • Structure

  • [PDB|2I1W] (from ''Listeria monocytogenes'', 60% identity) [Pubmed|17686780]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|yjbL]-[protein|search|sasB]-[protein|search|nadF]-[protein|search|yjbO]'' [Pubmed|18067544]

    • Regulation

  • expressed during exponential growth

    • Biological materials

    Mutant

  • 1A825 ( ''nadF''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A825&Search=1A825 BGSC]

    • References

  • 12897004,18067544,17686780