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rhaM
mutarotase involved in rhamnose utilization
function
utilization of rhamnose
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.12|Utilization of rhamnose]Gene
Coordinates
3,199,233 3,199,547
The protein
Catalyzed reaction/ biological activity
α-L-rhamnose --> β-L-rhamnose (according to UniProt)Protein family
rhamnose mutarotase family (single member, according to UniProt)Structure
[PDB|1X8D] (from E. coli, 55% identity) [pubmed|15876375][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|C32AE30BF7931D6171E9DE75C67504F81DD0F227|rhaEW]-[gene|F574142C1E61788FF8F4B61280AD4F87292D08DF|rhaR]-[gene|693040A5BA7A25AD485B7B28DBD6E8AAC77450F7|rhaB]-[gene|294C0CC675088B2A2EEFC26FAF1A628002B82C59|rhaM]-[gene|FDDC16D57752D81299CDD426257C1CD49890C89C|rhaA]
description
[Pubmed|26712933,22383849]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|26712933], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|F574142C1E61788FF8F4B61280AD4F87292D08DF|RhaR]: repression, [Pubmed|26712933], in [regulon|F574142C1E61788FF8F4B61280AD4F87292D08DF|RhaR regulon][protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|26712933], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]regulation
expression during spore [SW|germination] is increased under conditions of osmotic stress [Pubmed|27766092]view in new tabgenes
[gene|F574142C1E61788FF8F4B61280AD4F87292D08DF|rhaR]-[gene|693040A5BA7A25AD485B7B28DBD6E8AAC77450F7|rhaB]-[gene|294C0CC675088B2A2EEFC26FAF1A628002B82C59|rhaM]-[gene|FDDC16D57752D81299CDD426257C1CD49890C89C|rhaA]
description
[Pubmed|22383849]
regulation
expression during spore [SW|germination] is increased under conditions of osmotic stress [Pubmed|27766092]view in new tabBiological materials
Mutant
MGNA-A639 (yulD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/639 NBRP B. subtilis, Japan]BKE31190 ([gene|294C0CC675088B2A2EEFC26FAF1A628002B82C59|rhaM]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE31190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAACCTTTTCACCTCTTCA, downstream forward: _UP4_TGAAAAACTGATAAAGGGAGBKK31190 ([gene|294C0CC675088B2A2EEFC26FAF1A628002B82C59|rhaM]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK31190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAACCTTTTCACCTCTTCA, downstream forward: _UP4_TGAAAAACTGATAAAGGGAGReferences
26712933,24391637,22383849,27766092,15876375