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pncA

nicotinamidase

locus

BSU_31760

5.60

20.38 kDa

protein length

183 aa Sequence Blast

gene length

552 bp Sequence Blast

function

NAD salvage

product

nicotinamidase

essential

synonyms

yueJ

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]

Gene

Coordinates

3,260,891 3,261,442

The protein

Catalyzed reaction/ biological activity

deamination of nicotinamide to nicotinic acid [pubmed|30107912]

Protein family

[SW|Isochorismatase family] (according to UniProt)

Structure

[PDB|5ZN8]

[PDB|6A8L]

Expression and Regulation

Operons

genes

[gene|26430DCCEC263E7D03A3BBA4E7D636A250C3208B|pncA]-[gene|7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058|pncB]

description

[Pubmed|22383849]

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genes

description

[Pubmed|22383849]

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Biological materials

Mutant

MGNA-B563 (yueJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1562 NBRP B. subtilis, Japan]

BKE31760 ([gene|26430DCCEC263E7D03A3BBA4E7D636A250C3208B|pncA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE31760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGCCGGCCTCCCCGCCA, downstream forward: _UP4_GCAGAGTAAGGAAGGGGAAA

BKK31760 ([gene|26430DCCEC263E7D03A3BBA4E7D636A250C3208B|pncA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK31760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGCCGGCCTCCCCGCCA, downstream forward: _UP4_GCAGAGTAAGGAAGGGGAAA

References

Research papers

30107912