response regulator aspartate phosphatase, anti-activator protein, controls ComA activity
function
control of ComA activity
product
response regulator aspartate phosphatase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.4|Protein phosphatases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.2|Response regulator aspartate phosphatase][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][SW|Categories] containing this gene/protein
[SW|genetic competence], [SW|protein modification], [SW|transcription factors and their control], [SW|quorum sensing]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|ComA regulon]Gene
Coordinates on the chromosome (coding sequence)
3,846,001 -> 3,847,146
The protein
Catalyzed reaction/ biological activity
control of [protein|search|ComA] activity [Pubmed|15968044]Protein family
RAP family (according to Swiss-Prot)Effectors of protein activity
binding of [protein|search|PhrF] to [protein|search|RapF] results in a conformational change of [protein|search|RapF] and prevents it from binding [protein|search|ComA] [Pubmed|15968044,22215984]Structure
[PDB|3ULQ] (structure of the complex between the DNA-binding C-terminal domain of [protein|search|ComA] with [protein|search|RapF]) [Pubmed|22215984][SW|Interactions]
[protein|search|RapF]-[protein|search|ComA] [Pubmed|15968044,22215984][protein|search|RapF]-[protein|search|PhrF] [Pubmed|15968044,22215984]Expression and Regulation
Operon
''[protein|search|rapF]-[protein|search|phrF]'' [Pubmed|11466295]Regulation
repressed by glucose (5-fold) ([protein|search|CcpA]) [Pubmed|12850135]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|12850135][protein|search|ComA]: transcription activation [Pubmed|15968044]References
12850135,15968044,11466295,16091051,22215984 
