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ganR
transcriptional repressor of the galactan utilization operon
function
regulation of galactan utilization
product
transcriptional repressor ([SW|LacI family])
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.24|Utilization of galactan][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]Gene
Coordinates
3,508,659 3,509,651
The protein
Protein family
[SW|LacI family][SW|Domains]
[SW|HTH lacI-type domain] (aa 2-57) (according to UniProt)Effectors of protein activity
released from DNA upon binding of galactobiose [pubmed|22383849,27501980]Structure
[PDB|2HSG] (B. megaterium [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA], 25% identity) [pubmed|17500051]Expression and Regulation
Operons
genes
[gene|1F787F70C87DEB221709579122D63C2322A84E56|ganR]
description
[Pubmed|22383849]
regulatory mechanism
[protein|1F787F70C87DEB221709579122D63C2322A84E56|GanR]: repression, [pubmed|22383849], in [regulon|1F787F70C87DEB221709579122D63C2322A84E56|GanR regulon]regulation
induced by galactan (binding of galactobiose to [protein|1F787F70C87DEB221709579122D63C2322A84E56|GanR]) [Pubmed|28617843]view in new tabBiological materials
Mutant
GP815 ([gene|1F787F70C87DEB221709579122D63C2322A84E56|ganR]::spc) available in [SW|Jörg Stülke]'s labBKE34170 ([gene|1F787F70C87DEB221709579122D63C2322A84E56|ganR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE34170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTATCTGCCTCCATTA, downstream forward: _UP4_TAAGGATGACTTAGGACACTBKK34170 ([gene|1F787F70C87DEB221709579122D63C2322A84E56|ganR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK34170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTATCTGCCTCCATTA, downstream forward: _UP4_TAAGGATGACTTAGGACACTReferences
2104611,9287030,27501980,22383849,17500051