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gbsA [Fri Nov 13 2015 17:25:59 GMT+0100 (CET)]
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gbsA [Fri Nov 13 2015 17:25:59 GMT+0100 (CET)]

glycine betaine-aldehyde dehydrogenase, glycine betaine synthesis
locus
BSU31060
pI
4.00
mw
53.00 kDa
function
osmoprotection
product
glycine betaine-aldehyde dehydrogenase
essential
no
ec
1.2.1.8
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.4|Biosynthesis of glycine betaine]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]

    • [SW|Categories] containing this gene/protein

  • [SW|miscellaneous metabolic pathways], [SW|coping with hyper-osmotic stress]

    • This gene is a member of the following [SW|regulons]

  • [SW|GbsR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,185,092 -> 3,186,564

    The protein

    Catalyzed reaction/ biological activity

  • Betaine aldehyde NAD H2O = betaine NADH (according to Swiss-Prot)

    • Protein family

  • aldehyde dehydrogenase family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|YfmT], [protein|search|AldY], [protein|search|YcbD], [protein|search|GabD], [protein|search|DhaS], [protein|search|IolA], [protein|search|PutC], [protein|search|RocA], [protein|search|AldX], [protein|search|YwdH]

    • Structure

  • [http://pdb.org/pdb/explore/explore.do?structureId=4QTO 4QTO] (from ''Staphylococcus aureus'', 67% identity, 87% similarity)

    • Expression and Regulation

    Operon

  • '' [protein|search|gbsA]-[protein|search|gbsB]'' [Pubmed|8752328]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8752328]

    • Regulation

  • induced by choline ([protein|search|GbsR]) [Pubmed|22408163,8752328]

    • Regulatory mechanism

  • [protein|search|GbsR]: transcription repression [Pubmed|22408163]

    • Biological materials

    Mutant

  • 1A1056 ( ''gbsA''::''kan''), [Pubmed|21296969], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A1056&Search=1A1056 BGSC]

    • Labs working on this gene/protein

  • [SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

    • References

  • 9297465,8752328,21296969,22408163