copper transport protein, metallochaperone
function
resistance to copper
product
copper transport protein, metallochaperone
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.1|Copper][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.11|Resistance against toxic metals][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|resistance against toxic metals]This gene is a member of the following [SW|regulons]
[SW|CsoR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,443,613 -> 3,443,822
The protein
Catalyzed reaction/ biological activity
transfers Cu(I) to [SW|CopA] [Pubmed|28078344][SW|Cofactors]
carries a tetranuclear Cu(I) cluster (as [Cu4(S-Cys)4(N-His)2] cluster) [Pubmed|19746989]Structure
[PDB|2QIF][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|CopA]-[protein|search|CopZ], for the transfer of the Cu(I) cluster [Pubmed|19751213]Expression and Regulation
Operon
''[protein|search|copZ]-[protein|search|copA]'' [Pubmed|12779235][SW|Sigma factor]
[protein|search|SigA] [Pubmed|12779235]Regulation
induced by copper ([protein|search|CsoR]) [Pubmed|18048925,12779235]Regulatory mechanism
[protein|search|CsoR]: transcription repression [Pubmed|18048925]Labs working on this gene/protein
[SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]References
Reviews
Original publications
18361527,11922674,12590580,14663075,12779235,12644235,18048925,19170606,14514665,14711369,15212800,19170606,19746989,19751213,18419582,22370900,12238948,11980486,27197762,28078344 
