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nasF [Sat Jun 25 2016 16:30:37 GMT+0200 (CEST)]
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nasF [Sat Jun 25 2016 16:30:37 GMT+0200 (CEST)]

uroporphyrinogen methyltransferase
locus
BSU03280
pI
6.00
mw
53.00 kDa
function
nitrate respiration
product
uroporphyrinogen methyltransferase
essential
no
ec
2.1.1.107
synonyms
nasBE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.2|Anaerobic respiration]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.1|Utilization of nitrate/ nitrite]

    • [SW|Categories] containing this gene/protein

  • [SW|respiration], [SW|utilization of nitrogen sources other than amino acids]

    • This gene is a member of the following [SW|regulons]

  • [SW|Fur regulon], [SW|NsrR regulon], [SW|ResD regulon], [SW|TnrA regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    353,900 -> 355,351

    The protein

    Catalyzed reaction/ biological activity

  • S-adenosyl-L-methionine uroporphyrinogen III = S-adenosyl-L-homocysteine precorrin-1 (according to Swiss-Prot)

    • Protein family

  • precorrin methyltransferase family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [SW|YlnD]

    • Expression and Regulation

    Operon

  • ''[protein|search|nasB]-[protein|search|nasC]-[protein|search|nasD]-[protein|search|nasE]-[protein|search|nasF]'' [Pubmed|7836289]
  • ''[protein|search|nasD]-[protein|search|nasE]-[protein|search|nasF]'' [Pubmed|9765565]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|7836289]

    • Regulation

  • expressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8799114,9765565 PubMed]
  • ''[protein|search|nasD]'': expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10972836]
  • induced by nitric oxide under anaerobic conditions ([protein|search|NsrR]) [Pubmed|16885456]
  • induced by iron starvation ([protein|search|Fur]) [Pubmed|12354229]

    • Regulatory mechanism

  • [protein|search|TnrA]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8799114,9765565 PubMed]
  • [protein|search|ResD]: transcription activation [Pubmed|10972836]
  • [protein|search|NsrR]: transcription repression [Pubmed|16885456]
  • [protein|search|Fur]: transcription repression [Pubmed|12354229]

    • References

    Reviews

  • 22103536

    • Original publications

  • 10217486,12823818,24214949,8799114,9765565,10972836,16885456,7868621,21091510,25755103