ornithine carbamoyltransferase
function
biosynthesis of arginine
product
ornithine carbamoyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]This gene is a member of the following [SW|regulons]
[SW|AhrC regulon], [SW|CodY regulon]The protein
Catalyzed reaction/ biological activity
Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline (according to Swiss-Prot)Protein family
ATCase/OTCase family (according to Swiss-Prot)Structure
[PDB|2EF0] (from ''Thermus thermophilus hb8'', 48% identity, 63% similarity)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|argC]-[protein|search|argJ]-[protein|search|argB]-[protein|search|argD]-[protein|search|carA]-[protein|search|carB]-[protein|search|argF]'' [Pubmed|7511775][SW|Sigma factor]
[protein|search|SigA] [Pubmed|7511775]Regulation
repressed by casamino acids ([protein|search|CodY]) [Pubmed|12107147]repressed by arginine ([protein|search|AhrC]) [Pubmed|1312212]Regulatory mechanism
[protein|search|AhrC]: transcription repression [Pubmed|1312212][protein|search|CodY]: transcription repression [Pubmed|24843172]Biological materials
Mutant
1A605 ( ''argF''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A605&Search=1A605 BGSC]1A606 ( ''argF''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A606&Search=1A606 BGSC]References
6096675,24843172,12107147 
