uptake of succinate, fumurate, malate and oxaloacetate via proton symport
function
uptake of succinate, fumurate, malate and oxaloacetate
product
C4-dicarboxylate transport protein
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.6|Dicarboxylate/amino acid:cation symporter][category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.4|Transporter for organic acids][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|utilization of specific carbon sources], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|FsrA regulon]Gene
Coordinates on the chromosome (coding sequence)
500,166 -> 501,431
The protein
Catalyzed reaction/ biological activity
uptake of succinate, fumurate, malate and oxaloacetate via proton symport [Pubmed|20363944]acts as co-sensor for [protein|search|DctS] [Pubmed|24375102]Protein family
View classification (according to Swiss-Prot)Paralogous protein(s)
[protein|search|GltP], [protein|search|GltT]Structure
[http://pdb.org/pdb/explore/explore.do?structureId=4KY0 4KY0] (the glutamate transporter of ''Thermococcus kodakarensis'', 31% identity, 71% similarity) [Pubmed|24013209][SW|Localization]
cell membrane (according to Swiss-Prot)[SW|Interactions]
[protein|search|DctB]-[protein|search|DctS]-[protein|search|DctP], sensing complex [Pubmed|24375102]Expression and Regulation
Operon
''[protein|search|dctS]-[protein|search|dctR]-[protein|search|dctP]'' [Pubmed|10708364]''[protein|search|dctP]'' [Pubmed|10708364][SW|Sigma factor]
''[protein|search|dctP]'': [protein|search|SigA] [Pubmed|10708364]Regulation
repressed by glucose (6.2-fold) ([protein|search|CcpA]) [Pubmed|12850135]part of the iron sparing response, strong down-regulation in a'' [protein|search|fur]'' mutant ([protein|search|Fur], [protein|search|FsrA]) [Pubmed|22389480]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|12850135][protein|search|Fur]: indirect effect via control of ''[protein|search|fsrA]'' expression [Pubmed|22389480][protein|search|FsrA]: translation inhibition [Pubmed|22389480]References
12850135,10708364,10627041,12949159,20363944,22389480,22900538,24013209,24375102 
