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ylbQ [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]
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ylbQ [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

2-dehydropantoate 2-reductase
locus
BSU15110
pI
5.86
mw
33.00 kDa
function
biosynthesis of coenzyme A
product
2-dehydropantoate 2-reductase
essential
no
ec
1.1.1.169
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.4|Biosynthesis of coenzyme A]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • This gene is a member of the following [SW|regulons]

  • [SW|Spx regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,577,409 -> 1,578,305

    The protein

    Catalyzed reaction/ biological activity

  • (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH (according to Swiss-Prot)

    • Protein family

  • ketopantoate reductase family (according to Swiss-Prot)

    • Structure

  • [PDB|3LGO]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|ylbQ]-[protein|search|bshC]'' [Pubmed|20308541]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|23894131]

    • Regulation

  • induced by diamide stess (thiol depletion) ([protein|search|Spx]) [Pubmed|23894131]

    • Regulatory mechanism

  • [protein|search|Spx]: transcription activation [Pubmed|23894131]

    • References

    Operon and expression

  • 20308541,23894131