4.5 S RNA, causes RNA-driven elongation arrest by interaction with the 23S rRNA
function
presecretory protein translocation
product
small cytoplasmic RNA (scRNA, 4.5S RNA)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.3|Small cytoplasmatic RNA]Gene
Coordinates
26,533 → 26,635
Phenotypes of a mutant
the gene is essential [Pubmed|7506707]RNA
Structure
[PDB|4UE4] (complex [protein|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|Ffh]-[protein|097C817A5A3E31F73F6ABC4AA95852A64E43A057|Scr] RNA) [Pubmed|26344568]The protein
Structure
[PDB|4UE4] (complex [protein|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|Ffh]-[protein|097C817A5A3E31F73F6ABC4AA95852A64E43A057|Scr] RNA) [Pubmed|26344568]Expression and Regulation
Operons
genes
[gene|5FC8D0B30B55C1CBC2CDE8E56E7E948A781EF2AB|yaaJ]-[gene|097C817A5A3E31F73F6ABC4AA95852A64E43A057|scr]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, (both promoters), in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]view in new tabadditional information
the mature 5' end of the RNA is generated by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III]-mediated cleavage at 38 nts [pubmed|26883633]the mature 3' end of the RNA is generated by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y]-mediated cleavage at 320 nts, and further trimming to 308 nts [pubmed|25402410]Labs working on this gene/RNA
[SW|David Bechhofer], Mount Sinai School, New York, USA [http://www.mountsinai.org/Research/Centers Laboratories and Programs/Bechhofer Laboratory?citype=Physician&ciid=Bechhofer David H 1255565 Homepage]References
Reviews
Original publications
9346318,2468993,17576666,1372600,7506707,1383945,7538759,10224127,9677377,8662730,10222262,25270875,25402410,26883633,26344568 
