methionyl-tRNA formyltransferase
function
formylation of Met-tRNA(fMet)
product
methionyl-tRNA formyltransferase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation][category|SW 6|Groups of genes] → [category|SW 6.11|Efp-dependent proteins][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|Efp-dependent proteins]Gene
Coordinates on the chromosome (coding sequence)
1,646,999 -> 1,647,952
Phenotypes of a mutant
inactivation of ''[SW|fmt]'' suppresses the synthetic lethality of the ''[SW|defA] [SW|defB]'' double mutant [Pubmed|27983482]essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
10-formyltetrahydrofolate L-methionyl-tRNA(fMet) H2O = tetrahydrofolate N-formylmethionyl-tRNA(fMet) (according to Swiss-Prot) Protein family
fmt family (according to Swiss-Prot)Structure
[PDB|3RFO] (from ''Bacillus anthracis'', 69% identity, 89% similarity)Expression and Regulation
Operon
''[protein|search|defA]-[protein|search|fmt]-[protein|search|yloM]'' [Pubmed|16964327][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16964327]Additional information
[protein|search|translation] is likely to require [protein|search|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]References
8887566,19171795,27983482,12682299 
