function
arabinose utilization
product
L-arabinose isomerase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.6|Utilization of arabinan/ arabinose/ arabitol][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources]This gene is a member of the following [SW|regulons]
[SW|AraR regulon], [SW|CcpA regulon]The protein
Catalyzed reaction/ biological activity
L-arabinose = L-ribulose (according to Swiss-Prot)Protein family
arabinose isomerase family (according to Swiss-Prot)Kinetic information
k (cat) of 14,504 min(-1) and k (cat)/K (m) of 121 min(-1) mM(-1) for L-arabinose [Pubmed|19727704]Structure
[PDB|2AJT] (from ''Escherichia coli'', 51% identity, 71% similarity) [Pubmed|16756997]Expression and Regulation
Operon
''[protein|search|araA]-[protein|search|araB]-[protein|search|araD]-[protein|search|araL]-[protein|search|araM]-[protein|search|araN]-[protein|search|araP]-[protein|search|araQ]-[protein|search|abfA]'' [Pubmed|9084180][SW|Sigma factor]
[protein|search|SigA] [Pubmed|9084180]Regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|12949161]induced by arabinose ([protein|search|AraR]) [Pubmed|10417639]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|12949161][protein|search|AraR]: transcription repression [Pubmed|10417639]References
16585763,11418559,9084180,12949161,2500424,10417639,12949161,9084180,19727704 
