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pdeH [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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pdeH [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

c-di-GMP degrading phosphodiesterase
locus
BSU31740
pI
5.36
mw
47.00 kDa
function
degradation of c-di-GMP
product
c-di-GMP degrading phosphodiesterase
essential
no
ec
3.1.3.71
synonyms
yuxH, comB, yufA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.3|Metabolism of signalling nucleotides]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.5|Additional chemotaxis signal transduction and regulatory proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|metabolism of signalling nucleotides], [SW|motility and chemotaxis]

    • This gene is a member of the following [SW|regulons]

  • [SW|Spo0A regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,258,037 -> 3,259,266

    The protein

    Catalyzed reaction/ biological activity

  • degradation of c-di-GMP [Pubmed|23893111]

    • Protein family

  • comB family (according to Swiss-Prot)

    • [SW|Domains]

  • contains an EAL domain [Pubmed|22821967]

    • Expression and Regulation

    Operon

  • ''[protein|search|pdeH]'' [Pubmed|2507523]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|2507523]

    • Regulation

  • repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647,15687200]

    • Regulatory mechanism

  • [SW|Spo0A]: transcription repression [Pubmed|14651647,15687200]

    • Biological materials

    Mutant

  • GP1590 (kan) available in [SW|Jörg Stülke]'s lab

    • References

  • 14651647,15687200,2507523,22821967,23893111